Differences

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--- cohort [2020/04/28 15:44] – trynke
+++ cohort [2025/07/24 14:52] (current) – [Subcohorts] laura
@@ Line 1: / Line 1: @@
 ====== General Cohort & Factsheets ======
-The general cohort of [[Start|Lifelines]] consists of 167.729 participants, identified with a Lifelines-ID.\\
+The general population cohort of [[Start|Lifelines]] consists of 167.729 participants, identified with a Lifelines-ID.\\
 ===== Recruitment =====
 Lifelines participants were initially recruited through general practitioners in the three provinces in the [[location|northern part of the Netherlands]]: Groningen, Friesland and Drenthe((Scholtens, S., Smidt, N., Swertz, M.A., Bakker, S.J.L., Dotinga, A., Vonk, J.M., van Dijk, F., van Zon, S.K.R., Wijmenga, C., Wolffenbuttel, B.H.R., et al. (2015). Cohort Profile: LifeLines, a three-generation cohort study and biobank. Int. J. Epidemiol. 44, 1172–1180)).\\
-General practitioners invited all their patients between 25 and 50 years old (on Terschelling 18+), resulting in ~81.500 participants at [[1A|baseline]].\\
+General practitioners (GP's) invited all their patients between 25 and 50 years old (on Terschelling 18+), resulting in ~81.500 participants at [[1A|baseline]].\\
 These individuals were then asked to invite their family members (parents, partner, children, parents-in-law), resulting in an additional ~64.500 participants at [[1A|baseline]].\\
 ~21.500 interested individuals registered directly for [[1A|baseline]] participation via the Lifelines website.
@@ Line 36: / Line 36: @@
 Most questionnaires and measurements are performed in both sexes.\\
 Notable exceptions:
-  * [[ROAQ]], an [[additional assessments|additional assessment]] aimed at women
+  * [[ROAQ]], an [[additional assessments|additional assessment]] on reproductive health in women
-  * [[VESP]], an [[additional assessments|additional assessment]] aimed at men
+  * [[VESP]], an [[additional assessments|additional assessment]] on semen quality in men
   * [[NEXT]], our birth cohort with an emphasis on pregnant women (but fathers are also included)
-Thus far, the gender of participants was assessed via self-report and via [[https://www.government.nl/topics/personal-data/personal-records-database-brp|BRP]] linkage (both **binary**).\\
+Thus far, the *binary* gender of participants was assessed via self-report and via [[https://www.government.nl/topics/personal-data/personal-records-database-brp|BRP]] linkage.\\
-More recently, attention is given to [[https://en.wikipedia.org/wiki/Gender_identity|gender identity]] and [[https://en.wikipedia.org/wiki/Non-binary_gender|non-binary genders]] within the cohort.
+More recently, attention is given to *non-binary* [[sex & gender|gender]] within the cohort.
 ===== Nationality and Ethnicity =====
@@ Line 48: / Line 48: @@
 ===== Mortality =====
-As of July 2019, ~2000 participants have died. Although Lifelines continuously receives updates about the death of participants via the [[https://www.government.nl/topics/personal-data/personal-records-database-brp|BRP]], we do not know the [[https://en.wikipedia.org/wiki/Cause_of_death|cause of their death]]. Researchers interested in the causes of death may obtain this information via data linkage with [[http://www.cbs.nl/microdata|Statistics Netherlands]].
+Click [[mortality|here]] to learn more about the Lifelines death rate and causes of death.
 ===== Family connections =====
@@ Line 61: / Line 61: @@
 | Number of families       |        ^ Child(ren) = LL Participant(s)                             |||||
 ^ Parent = LL participant  | Total  | 1                               | 2      | 3     | 4    | 5    |
-| Mother                   | ~2200  | ~1500                           | ~600   | ~80   | <10  | <10  |
+| Only the mother          | ~2200  | ~1500                           | ~600   | ~80   | <10  | <10  |
-| Father                   | ~350   | ~250                            | ~80    | ~10   | <10  | <10  |
+| Only the father          | ~350   | ~250                            | ~80    | ~10   | <10  | <10  |
 | Mother and father        | ~5000  | ~2600                           | ~2000  | ~350  | ~40  | <10  |
+Other family connections (e.g. grandparent-grandchild, siblings) are present in the cohort as well.
@@ Line 74: / Line 76: @@
   * {{ :factsheet_asthma-copd_def.pdf |Asthma & COPD}}
+  * {{ :factsheet_frequency_of_cancer.pdf |Cancer}}
   * {{ :factsheet_diabetes_def.pdf |Diabetes}}
   * {{ :factsheet_cardiologie.pdf |Cardiovascular diseases}}
   * {{ :factsheet_mental_health.pdf |Mental health}}
-  * {{ :factsheet_prevalence_and_incidence_oct_2018.pdf |Disease prevalence}}
+  * {{ :factsheet_frequency_of_disease.pdf|Frequency of disease}}
   * {{ :factsheet_genetic_data.pdf |Omics data}}
   * {{ :factsheet_geo_health.pdf |Geolocation linkage}}
@@ Line 94: / Line 97: @@
   * [[DAG3]] subcohort (9,500 participants with extensive metabolomics/microbiomics)
+{{ :omics.jpg?400 |}}
 ===== Data Linkage =====
@@ Line 100: / Line 104: @@
   * Individual data from **governmental registries** (i.e. causes of death, socio-economic data) can  be linked to Lifelines health-related data via [[http://www.cbs.nl/microdata|Statistics Netherlands]]
   * Individual results from **pathological tests** (i.e. biopsies) can be linked to Lifelines health-related data (including self-reported [[cancer]]) via [[https://www.palga.nl|PALGA]] and [[https://www.zorgttp.nl|ZorgTTP]]
-  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://www.iadb.nl|IADB]]
+  * Individual longitudinal **prescription medication** data from Dutch pharmacies can be linked to Lifelines health-related data (including self-reported [[medication]]) via [[http://www.iadb.nl|IADB]] (the {{ ::pharmlines_procedures_20210415.pdf|Pharmlines}} initiative). Data on prescription medication can be linked for approximately 110.000 Lifelines participants.