dag2
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| ====== DAG2 ====== | ====== DAG2 ====== | ||
| - | DAG2 is one of Lifelines' [[additional assessments]] performed in collaboration with the UMCG [[https://www.systemsgenetics.nl/|department of genetics]] (see also: [[DEEP|DAG1]] and [[DAG3]]). DAG is the abbreviation of DArmGezondheid, or "Gastrointestinal health" in Dutch.\\ | + | DAG2 is one of [[start|Lifelines]]' [[additional assessments]] performed in collaboration with the UMCG [[https://www.systemsgenetics.nl/|department of genetics]] (see also: [[DEEP|DAG1]], [[DAG3]], [[DAG4]] and [[DAG5]]). DAG is the abbreviation of DArmGezondheid, or "Gastrointestinal health" in Dutch.\\ |
| - | DAG2 comprised of the collection and analyses of samples and data following the same protocol as [[DEEP|DAG1]], in a small group of Lifelines participants that had previously been included in the [[http://www.nlgenome.nl/|GoNL]] project. For these participants, the whole genome sequence was analysed. | + | DAG2 comprised of the collection and analyses of blood, breath, and faecal samples plus gastrointestinal questionnaire data following the same protocol as [[DEEP|DAG1]], in a small group of Lifelines participants that had previously been included in the [[http://www.nlgenome.nl/|GoNL]] project. |
| =====Subcohort===== | =====Subcohort===== | ||
| - | DAG2 included approximately 110 adult Lifelines participants that had previously been selected for the [[http://www.nlgenome.nl/|GoNL]] project.\\ | + | |
| - | In this consortium project, the [[https://en.wikipedia.org/wiki/Whole_genome_sequencing|whole genome]] of 250 Dutch parent-offspring families were sequenced. In total five Dutch biobanks contributed samples: Lifelines, [[http://www.leidenlangleven.nl/nl/home|Leiden Longevity Study]], [[http://www.tweelingenregister.org/en/information/|Netherlands Twin Registry]], [[http://www.ergo-onderzoek.nl/wp/|Rotterdam Study]] and [[http://www.epib.nl/research/erf/erf_index.html|Rucphen Study]]).\\ | + | DAG2 included approximately 110 adult Lifelines participants from the 55 parent-parent-child trio’s whose blood samples (165 samples total) were donated to the [[http://www.nlgenome.nl/|GoNL]] project for [[https://en.wikipedia.org/wiki/Whole_genome_sequencing|whole genome sequencing]]((Francioli LC et al. (2014) Whole-genome sequence variation, population structure and demographic history of the Dutch population. Nature Genetics 46(8): 818-825)).\\ |
| - | Lifelines contributed samples of 55 parent-parent-child trio’s (165 samples total) to the GoNL project ((Francioli LC et al. (2014) Whole-genome sequence variation, population structure and demographic history of the Dutch population. Nature Genetics 46(8): 818-825)) | + | In this consortium project, a total of 250 Dutch parent-offspring families were sequenced. Five Dutch biobanks contributed samples: Lifelines, the [[http://www.leidenlangleven.nl/nl/home|Leiden Longevity Study]], the [[http://www.tweelingenregister.org/en/information/|Netherlands Twin Registry]], the [[http://www.ergo-onderzoek.nl/wp/|Rotterdam Study]] and the [[http://www.epib.nl/research/erf/erf_index.html|Rucphen Study]].\\ |
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