dag5
Differences
This shows you the differences between two versions of the page.
| Next revision | Previous revision | ||
|
dag5 [2024/11/25 16:24] anna created |
dag5 [2025/02/05 14:49] (current) |
||
|---|---|---|---|
| Line 1: | Line 1: | ||
| ====== DAG5 ====== | ====== DAG5 ====== | ||
| - | DAG5 is one of Lifelines' [[additional assessments]] (see also: [[DEEP|DAG1]], [[DAG2]], [[DAG3]] and [[DAG5]]). DAG is the abbreviation of DArmGezondheid, or "Gastrointestinal health" in Dutch.\\ | + | DAG5 is one of Lifelines' [[additional assessments]] (see also: [[DEEP|DAG1]], [[DAG2]], [[DAG3]] and [[DAG4]]). DAG is the abbreviation of DArmGezondheid, or "Gastrointestinal health" in Dutch.\\ |
| + | |||
| + | ===== Background ===== | ||
| + | |||
| + | There is increasing insight into the role of bacterial composition in the intestine and upon the occurrence of (chronic) diseases. Previous research in DAG1 ([[DEEP]]) demonstrated the relation of the microbiome and lipids, but also many other diseases and intrinsic and extrinsic factors. Previous research in DAG3 ([[DAG3]]) described the gut microbioom in a larger cohort. | ||
| + | |||
| + | Longitudinal analyses in 350 Lifelines DEEP participants that were also part of the DAG3 collection, showed that microbiome individual specific patterns could be stable for >3 years. However, it was also observed that some microbial changes were related to individual’s changes over time were in line with individual’s changes in their healthy status, lifestyle and medication usage (REFERENCE). | ||
| + | |||
| + | The purpose of DAG4 was to extent the amount of participants with longitudinal data and longitudinal biological samples, that gives an unique opportunity to study the long-term dynamics of the gut microbiome and its relation to developing and progressing of diseases and phenotypes. | ||
| + | |||
| + | In DAG5 another follow up stool sample is collected. | ||
| + | |||
| + | ===== Subcohort ===== | ||
| + | A total of approximately <NUMBER> participants were included in the DAG5 dataset. All participants we aged 18 years or older. | ||
| + | |||
| + | Besides the samples used to generate the microbiome data, questionnaires were also sent to participants to gather phenotypic data on gastrointestinal health symptoms by means of [[Functional bowel symptoms (Rome III)|Rome III]] criteria questionnaire (Longstreth etal 2006) and the Bristol Stool Form Scale (O’Donnell etal 1990). | ||
dag5.1732548283.txt.gz · Last modified: 2025/02/05 14:49 (external edit)
Page Tools
Except where otherwise noted, content on this wiki is licensed under the following license: CC Attribution-Noncommercial-Share Alike 4.0 International
