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--- family_relations [2023/07/11 09:40] – simone
+++ family_relations [2025/09/02 10:45] (current) – simone
@@ Line 5: / Line 5: @@
 The basis of the family relations data within Lifelines consists of information from the municipal registries (Basisregistratie Personen (BRP)). Based on this information, researchers from the [[ugli|UGLI-consortium]] have optimized the family relations using recoded surname data (for privacy purposes) and data from questionnaires ([[family_composition|Family composition]]). The process of this optimization has been documented and can be found here: {{ :lifelines_familyreconstruction.pdf | Family relations reconstruction}}.
-These optimized family relations were then verified by the UGLI-consortium using available genetic data. The most recent version of the family relations data (sec_family_relations_v3.1) has been verified by using genetic data from [[gwas|GWAS (CytoSNP)]], [[ugli|UGLI 1 (GSA), and UGLI 2 (Affymetrix)]]. More detailed information on this process can be found in the quality control document of UGLI2-Affymetrix: {{ :QC_report_UGLI2_(release_1)-v1.pdf |QC_report_UGLI2_(release_1)-v1.pdf}}, page 6 - 9, section 6b and in the {{ :readme_family_relations_v3.1.pdf |readme of the familyrelations}}.
+These optimized family relations were then verified by the UGLI-consortium using available genetic data. The most recent version of the family relations data (sec_family_relations_v3.1; July 2023) has been verified by using genetic data from [[gwas|GWAS (CytoSNP)]], [[ugli|UGLI 1 (GSA), and UGLI 2 (Affymetrix)]]. More detailed information on this process can be found in the quality control document of UGLI2-Affymetrix: {{ :QC_report_UGLI2_(release_1)-v1.pdf |QC_report_UGLI2_(release_1)-v1.pdf}}, page 6 - 9, section 6b and in the {{ :readme_family_relations_v3.1.pdf |readme of the familyrelations}}.
 Note that the family relations file does not provide information on whether a family member lives in the same house. Information on [[default_variables|postal code 4]] is available in your data by default and data on [[household_composition|household composition]] can be requested through our [[https://data-catalogue.lifelines.nl/|catalogue]].
-===== Data and structure =====
+The family relations file is not available through our catalogue, but can be requested by sending an e-mail to data@lifelines.nl (this does not apply to UGLI consortium cluster users, who can already find the file in pheno_lifelines). If you do not already have access to the family relation file, please also complete our [[https://www.lifelines.nl/researcher/how-to-apply|amendment form]].
+===== Data and Structure =====
 The data in sec_family_relations_v3.1 consists of 5 columns:
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 The family id is used to identify participants that are part of the same family. Couples who share a household, but don't have children, also receive a family id. This provides the opportunity to work on research involving environmental factors. Note that partner information is based on [[1A|baseline data]].
+===== Family Duos and Trios =====
+From the family relations file the following numbers have been extracted:
+{{:family_relations.png?600|}}
+===== Twins and Triplets =====
+Based on birth and family records, the following numbers were identified within Lifelines:
+  * Twins: 632 pairs (1,264 unique individuals)
+      * Monozygotic (MZ): 152 pairs
+      * Dizygotic (DZ): 350 pairs
+      * Zygosity undetermined: 130 pairs
+  * Triplets: 6 sets (18 unique individuals). As far as could be ascertained, none of these sets included  monozygotic pairs or trios.
+The classification of twin zygosity was determined using a combination of DNA data, sex, and questionnaire responses (see Table 1).
+^ Method                                 ^ DZ   ^ MZ   ^
+| DNA                                    | 134  | 124  |
+| Mixed gender                           | 187  | –    |
+| Questionnaire completed by both twins  | 10   | 15   |
+| Questionnaire completed by one twin    | 19   | 13   |
+| Total                                  | 350  | 152  |