family_relations
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| The basis of the family relations data within Lifelines consists of information from the municipal registries (Basisregistratie Personen (BRP)). Based on this information, researchers from the [[ugli|UGLI-consortium]] have optimized the family relations using recoded surname data (for privacy purposes) and data from questionnaires ([[family_composition|Family composition]]). The process of this optimization has been documented and can be found here: {{ :lifelines_familyreconstruction.pdf | Family relations reconstruction}}. | The basis of the family relations data within Lifelines consists of information from the municipal registries (Basisregistratie Personen (BRP)). Based on this information, researchers from the [[ugli|UGLI-consortium]] have optimized the family relations using recoded surname data (for privacy purposes) and data from questionnaires ([[family_composition|Family composition]]). The process of this optimization has been documented and can be found here: {{ :lifelines_familyreconstruction.pdf | Family relations reconstruction}}. | ||
| - | These optimized family relations were then verified by the UGLI-consortium using available genetic data. The most recent version of the family relations data (sec_family_relations_v3.1) has been verified by using genetic data from [[gwas|GWAS (CytoSNP)]], [[ugli|UGLI 1 (GSA), and UGLI 2 (Affymetrix)]]. More detailed information on this process can be found in the quality control document of UGLI2-Affymetrix: {{ :QC_report_UGLI2_(release_1)-v1.pdf |QC_report_UGLI2_(release_1)-v1.pdf}}, page 6 - 9, section 6b and in the {{ :readme_family_relations_v3.1.pdf |readme of the familyrelations}}. | + | These optimized family relations were then verified by the UGLI-consortium using available genetic data. The most recent version of the family relations data (sec_family_relations_v3.1; July 2023) has been verified by using genetic data from [[gwas|GWAS (CytoSNP)]], [[ugli|UGLI 1 (GSA), and UGLI 2 (Affymetrix)]]. More detailed information on this process can be found in the quality control document of UGLI2-Affymetrix: {{ :QC_report_UGLI2_(release_1)-v1.pdf |QC_report_UGLI2_(release_1)-v1.pdf}}, page 6 - 9, section 6b and in the {{ :readme_family_relations_v3.1.pdf |readme of the familyrelations}}. |
| Note that the family relations file does not provide information on whether a family member lives in the same house. Information on [[default_variables|postal code 4]] is available in your data by default and data on [[household_composition|household composition]] can be requested through our [[https://data-catalogue.lifelines.nl/|catalogue]]. | Note that the family relations file does not provide information on whether a family member lives in the same house. Information on [[default_variables|postal code 4]] is available in your data by default and data on [[household_composition|household composition]] can be requested through our [[https://data-catalogue.lifelines.nl/|catalogue]]. | ||
| - | ===== Data and structure ===== | + | The family relations file is not available through our catalogue, but can be requested by sending an e-mail to data@lifelines.nl (this does not apply to UGLI consortium cluster users, who can already find the file in pheno_lifelines). If you do not already have access to the family relation file, please also complete our [[https://www.lifelines.nl/researcher/how-to-apply|amendment form]]. |
| + | |||
| + | ===== Data and Structure ===== | ||
| The data in sec_family_relations_v3.1 consists of 5 columns: | The data in sec_family_relations_v3.1 consists of 5 columns: | ||
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| The family id is used to identify participants that are part of the same family. Couples who share a household, but don't have children, also receive a family id. This provides the opportunity to work on research involving environmental factors. Note that partner information is based on [[1A|baseline data]]. | The family id is used to identify participants that are part of the same family. Couples who share a household, but don't have children, also receive a family id. This provides the opportunity to work on research involving environmental factors. Note that partner information is based on [[1A|baseline data]]. | ||
| + | ===== Family Duos and Trios ===== | ||
| + | From the family relations file the following numbers have been extracted: | ||
| + | |||
| + | {{:family_relations.png?600|}} | ||
| + | |||
| + | ===== Twins and Triplets ===== | ||
| + | Based on birth and family records, the following numbers were identified within Lifelines: | ||
| + | * Twins: 632 pairs (1,264 unique individuals) | ||
| + | * Monozygotic (MZ): 152 pairs | ||
| + | * Dizygotic (DZ): 350 pairs | ||
| + | * Zygosity undetermined: 130 pairs | ||
| + | * Triplets: 6 sets (18 unique individuals). As far as could be ascertained, none of these sets included monozygotic pairs or trios. | ||
| + | |||
| + | The classification of twin zygosity was determined using a combination of DNA data, sex, and questionnaire responses (see Table 1). | ||
| + | ^ Method ^ DZ ^ MZ ^ | ||
| + | | DNA | 134 | 124 | | ||
| + | | Mixed gender | 187 | – | | ||
| + | | Questionnaire completed by both twins | 10 | 15 | | ||
| + | | Questionnaire completed by one twin | 19 | 13 | | ||
| + | | Total | 350 | 152 | | ||
family_relations.1689068457.txt.gz · Last modified: 2025/02/05 14:49 (external edit)
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