Differences

This shows you the differences between two versions of the page.

--- hscrp [2020/12/17 12:07] – [Table] trynke
+++ hscrp [2025/10/09 14:59] (current) – simone
@@ Line 1: / Line 1: @@
 ====== hsCRP measurements ======
-High-sensitivity [[https://en.wikipedia.org/wiki/C-reactive_protein|CRP]] (hsCRP) levels in [[start|Lifelines]] participants were  determined in [[blood analyses|blood samples]] using three different lab-methods ([[sections|section]]: [[Physical state]].\\
+High-sensitivity [[https://en.wikipedia.org/wiki/C-reactive_protein|CRP]] (hsCRP) levels in [[start|Lifelines]] participants were  determined in [[blood analyses|blood samples]] ([[sections|section]]: [[Physical state]]) using three different lab-methods.\\
 The difference between the three methods are stated in the table.\\
-[[hsCRP]] in heparin (mg/L)	hscrp_result_all_m_2	LCRP	~49k	-	8+
+^ Variable code         ^ Variable name  ^ Kit name           ^ Supplier         ^ Tube type  ^ Participants                     ^
-[[hsCRP]] in serum (mg/L)	hscrp_result_all_m_1	SCRP	~8k	-	8+
+| hscrp_result_all_m_1  | SCRP           | CardioPhase hsCRP  | Siemens (BNII)   | Serum      | ~8k ([[1A]])                     |
-[[hsCRP]] in heparin (mg/L)	hscrp_result_all_m_3	CRPH	~1k	~500	8+
+| hscrp_result_all_m_2  | LCRP           | CardioPhase hsCRP  | Siemens (BNII)   | Heparin    | ~49k ([[1A]])                    |
-^ Variable code         | Variable name  | Kit name           | Supplier name    | Tube type  | Participants                     |
-| hscrp_result_all_m_1  | SCRP           | CardioPhase hsCRP  | Siemens (BNII)   | Serum      | ~49k ([[1A]])                    |
-| hscrp_result_all_m_2  | LCRP           | CardioPhase hsCRP  | Siemens (BNII)   | Heparin    | ~8k ([[1A]])                     |
 | hscrp_result_all_m_3  | CRPH           | CRPL3              | Roche (Modular)  | Heparin    | ~1k ([[1A]]) and ~0.5k ([[2A]])  |
-CRPH and LCRP only differ in the supplier. This does not have an effect on the measured values.\\
+hscrp_result_all_m_1 and hscrp_result_all_m_2 only differ in the tube type. This has not affected the measured values (externally validated in N=100 samples).
-SCRP differs from CRPH and LCRP in the type of tube used to collect the sample.\\
+hscrp_result_all_m_1 and hscrp_result_all_m_2 differ from hscrp_result_all_m_3 in the supplier of the assay. This causes differences in the measured values. hscrp_result_all_m_1 and hscrp_result_all_m_2 values can be adjusted to be similar to hscrp_result_all_m_3 using the formula: //adjusted variable = 0.92 x unadjusted - 0.01//, that is //hscrp_result_all_m_1_adjusted = 0.92 x hscrp_result_all_m_1 – 0.01// and //hscrp_result_all_m_2_adjusted = 0.92 x hscrp_result_all_m_2 – 0.01//.
-This causes differences in the measured values. SCRP values can be converted to LCRP using the formula: 0.92X - 0.01.
+**Please note:**
+- Until October 2025, this information was displayed wrongly on the wiki page. It was mistakenly mentioned that difference in supplier did not have an effect on measured values, while difference in tube type did have an effect. This is the other way around. A wrong formula was displayed (//hscrp_result_all_m_1 = 0.92 x hscrp_result_all_m_2/3 – 0.01//)
+- 3A hscrp_result_all_m_1 data was mistakenly released until May 2025.