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| mini_mental_state_examination [2020/03/09 16:04] – trynke | mini_mental_state_examination [2025/02/05 13:49] (current) – external edit 127.0.0.1 |
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| ====== Mini Mental State Examination (MMSE) ====== | ====== Mini Mental State Examination (MMSE) ====== |
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| | The Mini International Neuropsychiatric Interview (MINI) ([[sections|section]]: [[mental health]]) was measured in all elderly [[start|Lifelines]] participants during: |
| | * [[1A Visit 1]] (65+, n = ~13.000) |
| | * [[3A Visit 1]] (65+) |
| | |
| | ===== Background ===== |
| The Mini Mental State Examination ([[https://en.wikipedia.org/wiki/Mini%E2%80%93Mental_State_Examination|MMSE]]) is a brief cognition test used to assess cognitive impairments ([[sections|section]]: [[mental health]]). It is commonly used in medicine and allied health to screen for dementia.\\ | The Mini Mental State Examination ([[https://en.wikipedia.org/wiki/Mini%E2%80%93Mental_State_Examination|MMSE]]) is a brief cognition test used to assess cognitive impairments ([[sections|section]]: [[mental health]]). It is commonly used in medicine and allied health to screen for dementia.\\ |
| The MMSE was performed in ca. 12.000 [[elderly]] (65+) participants during [[1A Visit 1]]. ~12% scored below 24 points. The MMSE is implemented again in [[3A Visit 1]]\\ | The MMSE was performed in ca. 12.000 [[elderly]] (65+) participants during [[1A Visit 1]]. ~12% scored below 24 points (NB: in case of an MMSE score <26 at [[1A visit 1]], the [[Proxy]] interview was performed on location).\\ The MMSE is implemented again in [[3A Visit 1]]\\ |
| The MMSE is used in conjunction with other cognition tests in [[start|Lifelines]], i.e. the [[Ruff Figural Fluency Test|RFFT]] (also during [[1A Visit 1]] and [[3A Visit 1]]) and the [[CogState]] (during [[2A visit 1]] and [[3A Visit 1]]), and with several [[cognition (general)|cognition-related questions]]. | The MMSE is used in conjunction with other cognition tests in [[start|Lifelines]], i.e. the [[Ruff Figural Fluency Test|RFFT]] (also during [[1A Visit 1]] and [[3A Visit 1]]) and the [[CogState]] (during [[2A visit 1]] and [[3A Visit 1]]), and with several [[cognition (general)|cognition-related questions]]. |
| The MMSE should not be confused with the [[Mini Neuropsychiatric Interview]], which is also used in Lifelines but assesses anxiety and depression.\\ | The MMSE should not be confused with the [[Mini Neuropsychiatric Interview]], which is also used in Lifelines but assesses anxiety and depression.\\ |
| |
| ===== Background ===== | |
| De MMSE includes simple questions and tasks in a number of areas: | De MMSE includes simple questions and tasks in a number of areas: |
| * orientation (V1a-e, V2a-e, max. 10 points); | * orientation (V1a-e, V2a-e, max. 10 points); |
| * 18-23 points: Mild to moderate cognitive impairment | * 18-23 points: Mild to moderate cognitive impairment |
| * 0-17 points: Severe cognitive impairment | * 0-17 points: Severe cognitive impairment |
| Note that in Lifelines, the final score is calculated as the sum of all variable-scores minus 18 (since 18 variables automatically received 1 extra point to all options). | Note that in Lifelines, the computer programme gave the following raw data scores: |
| | * 12 out of 30 items were scored as 1 for correct and 0 for incorrect |
| | * 18 out of 30 items were scored as 2 for correct and 1 for incorrect |
| | The programme therefore subtracted 1 from each score in these 18 items to get the final score.\\ |
| | When raw MMSE data are used for calculations, the same subtraction should be made.\\ |
| The Lifelines protocol of the MMSE (in Dutch) can be downloaded here: {{ :mmse_in_dutch.pdf |}}\\ | The Lifelines protocol of the MMSE (in Dutch) can be downloaded here: {{ :mmse_in_dutch.pdf |}}\\ |
| The English equivalent can be downloaded here: {{ :mmse_in_english.pdf |}} | The English equivalent can be downloaded here: {{ :mmse_in_english.pdf |}} |
| |
| ==== Variables ==== | ===== Variables ===== |
| |
| | **English** | **Dutch** | **Variable** | **Assessment** | **Age** | | | **English** | **Dutch** | **Code** | **Variable** | **Assessment** | **Age** | |
| | What year is it? (Correct?) | Welk jaar is het? (Correct?) | V1A | [[1A Visit 1]] | 65+ | | | What year is it? (Correct?) | Welk jaar is het? (Correct?) | mmse_time_adu_m_01_a | V1A | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | What season is it? (Correct?) | Welk seizoen is het? (Correct?) | V1B | [[1A Visit 1]] | 65+ | | | What season is it? (Correct?) | Welk seizoen is het? (Correct?) | mmse_time_adu_m_01_b | V1B | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Which month of the year is it? (Correct?) | Welke maand van het jaar is het? (Correct?) | V1C | [[1A Visit 1]] | 65+ | | | Which month of the year is it? (Correct?) | Welke maand van het jaar is het? (Correct?) | mmse_time_adu_m_01_c | V1C | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | What is today's date? (Correct?) | Wat is de datum van vandaag? (Correct?) | V1D | [[1A Visit 1]] | 65+ | | | What is today's date? (Correct?) | Wat is de datum van vandaag? (Correct?) | mmse_time_adu_m_01_d | V1D | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | What day of the week is it today? (Correct?) | Welke dag van de week is het? (Correct) | V1E | [[1A Visit 1]] | 65+ | | | What day of the week is it today? (Correct?) | Welke dag van de week is het? (Correct) | mmse_time_adu_m_01_e | V1E | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | In which province are we now? (Correct?) | In welke provincie zijn we nu? (Correct?) | V2A | [[1A Visit 1]] | 65+ | | | In which province are we now? (Correct?) | In welke provincie zijn we nu? (Correct?) | mmse_place_adu_m_02_a | V2A | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | In what city or town are we now? (Correct?) | In welke plaats zijn we nu? (Correct?) | V2B | [[1A Visit 1]] | 65+ | | | In what city or town are we now? (Correct?) | In welke plaats zijn we nu? (Correct?) | mmse_place_adu_m_02_b | V2B | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | In what street are we now? (Correct?) | In welke straat zijn we nu? (Correct?) | V2C | [[1A Visit 1]] | 65+ | | | In what street are we now? (Correct?) | In welke straat zijn we nu? (Correct?) | mmse_place_adu_m_02_c | V2C | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | What is this building called? (Correct?) | Hoe heet dit gebouw? (Correct?) | V2D | [[1A Visit 1]] | 65+ | | | What is this building called? (Correct?) | Hoe heet dit gebouw? (Correct?) | mmse_place_adu_m_02_d | V2D | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | On what floor are we now? (Correct?) | Op welke verdieping zijn we nu? (Correct?) | V2E | [[1A Visit 1]] | 65+ | | | On what floor are we now? (Correct?) | Op welke verdieping zijn we nu? (Correct?) | mmse_place_adu_m_02_e | V2E | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | I will name three objects now. Could you repeat them after I've said all three? Apple. (Correct?) | Ik noem nu drie voorwerpen. Wilt u die herhalen nadat ik ze alle drie gezegd heb? Appel. (Correct?) | V3A | [[1A Visit 1]] | 65+ | | | I will name three objects now. Could you repeat them after I've said all three? Apple. (Correct?) | Ik noem nu drie voorwerpen. Wilt u die herhalen nadat ik ze alle drie gezegd heb? Appel. (Correct?) | mmse_object_adu_m_03_a | V3A | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Key. (Correct?) | Sleutel. (Correct?) | V3B | [[1A Visit 1]] | 65+ | | | Key. (Correct?) | Sleutel. (Correct?) | mmse_object_adu_m_03_b | V3B | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Table. (Correct?) | Tafel. (Correct?) | V3C | [[1A Visit 1]] | 65+ | | | Table. (Correct?) | Tafel. (Correct?) | mmse_object_adu_m_03_c | V3C | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Could you subtract seven from 100 and subtract seven again from that number and keep going like that? (score: 0-5 points) | Wilt u van de 100 zeven aftrekken en van wat overblijft weer zeven aftrekken en zo doorgaan? (score: 0-5 punten) | V4 | [[1A Visit 1]] | 65+ | | | Could you subtract seven from 100 and subtract seven again from that number and keep going like that? (score: 0-5 points) | Wilt u van de 100 zeven aftrekken en van wat overblijft weer zeven aftrekken en zo doorgaan? (score: 0-5 punten) | mmse_calculation_adu_m_04 | V4 | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Could you mention again the three objects I just named? Apple. (Correct?) | Noemt u nogmaals de drie voorwerpen van zojuist. Appel. (Correct?) | V5A | [[1A Visit 1]] | 65+ | | | Could you mention again the three objects I just named? Apple. (Correct?) | Noemt u nogmaals de drie voorwerpen van zojuist. Appel. (Correct?) | mmse_recall_adu_m_05_a | V5A | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Key. (Correct?) | Sleutel. (Correct?) | V5B | [[1A Visit 1]] | 65+ | | | Key. (Correct?) | Sleutel. (Correct?) | mmse_recall_adu_m_05_b | V5B | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Table. (Correct?) | Tafel. (Correct?) | V5C | [[1A Visit 1]] | 65+ | | | Table. (Correct?) | Tafel. (Correct?) | mmse_recall_adu_m_05_c | V5C | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | What is this? Pen. (Correct?) | Wat is dit? Pen. (Correct?) | V6A | [[1A Visit 1]] | 65+ | | | What is this? Pen. (Correct?) | Wat is dit? Pen. (Correct?) | mmse_object_adu_m_06_a | V6A | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | And what is that? Watch. (Correct?) | En wat is dat? Horloge. (Correct?) | V6B | [[1A Visit 1]] | 65+ | | | And what is that? Watch. (Correct?) | En wat is dat? Horloge. (Correct?) | mmse_object_adu_m_06_b | V6B | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Could you repeat the following sentence: Now this, and then that again. (Correct?) | Wilt u de volgende zin herhalen: Nu eens dit en dan weer dat. (Correct?) | V7 | [[1A Visit 1]] | 65+ | | | Could you repeat the following sentence: Now this, and then that again. (Correct?) | Wilt u de volgende zin herhalen: Nu eens dit en dan weer dat. (Correct?) | mmse_language_adu_m_07 | V7 | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Could you please read these words and then do what they say? (Paper on which is written in large letters: Close your eyes.) (Correct?) | Wilt u deze woorden lezen en dan doen wat er staat?(Papier met daarop in grote letters: Sluit uw ogen.) (Correct?) | V8 | [[1A Visit 1]] | 65+ | | | Could you please read these words and then do what they say? (Paper on which is written in large letters: Close your eyes.) (Correct?) | Wilt u deze woorden lezen en dan doen wat er staat?(Papier met daarop in grote letters: Sluit uw ogen.) (Correct?) | mmse_language_adu_m_08 | V8 | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Could you pick up this paper with your right hand, fold it in two and then put it on your lap? (Right hand, correct?) | Wilt u dit papiertje pakken met uw rechterhand, het dubbelvouwen en het op uw schoot leggen? (Rechter hand, correct?) | V9A | [[1A Visit 1]] | 65+ | | | Could you pick up this paper with your right hand, fold it in two and then put it on your lap? (Right hand, correct?) | Wilt u dit papiertje pakken met uw rechterhand, het dubbelvouwen en het op uw schoot leggen? (Rechter hand, correct?) | mmse_motor_adu_m_09_a | V9A | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Is the paper folded? | Is het papiertje dubbelgevouwen? | V9B | [[1A Visit 1]] | 65+ | | | Is the paper folded? | Is het papiertje dubbelgevouwen? | mmse_motor_adu_m_09_b | V9B | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Was the paper placed on the lap? | Is het papiertje op de schoot gelegd? | V9C | [[1A Visit 1]] | 65+ | | | Was the paper placed on the lap? | Is het papiertje op de schoot gelegd? | mmse_motor_adu_m_09_c | V9C | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Could you write a complete sentence on this piece of paper? (Correct?) | Wilt u voor mij een volledige zin opschrijven op dit stuk papier? (Correct?) | V10 | [[1A Visit 1]] | 65+ | | | Could you write a complete sentence on this piece of paper? (Correct?) | Wilt u voor mij een volledige zin opschrijven op dit stuk papier? (Correct?) | mmse_write_adu_m_10 | V10 | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | Could you copy this figure? (Correct?) | Wilt u deze figuur natekenen? (Correct?) | V11 | [[1A Visit 1]] | 65+ | | | Could you copy this figure? (Correct?) | Wilt u deze figuur natekenen? (Correct?) | mmse_draw_adu_m_11 | V11 | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
| | MMSE total score | MMSE totaal score | SCORE | [[1A Visit 1]] | 65+ | | | MMSE total score | MMSE totaal score | mmse_score_adu_m_01 | SCORE | [[1A Visit 1|1A]] [[3A Visit 1|3A]] | 65+ | |
