skin_autofluorescence
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skin_autofluorescence [2020/05/18 13:37] trynke |
skin_autofluorescence [2025/02/05 14:49] (current) |
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| ====== Skin Autofluorescence ====== | ====== Skin Autofluorescence ====== | ||
| - | Skin [[https://en.wikipedia.org/wiki/Autofluorescence|autofluorescence]] (SAF) ([[sections|section]]: [[physical state]]) was measured were taken in adult [[start|Lifelines]] participants during [[1A Visit 1]] (n = ~84.000, n = ~76,000 after quality control). | + | Skin [[https://en.wikipedia.org/wiki/Autofluorescence|autofluorescence]] (SAF) ([[sections|section]]: [[physical state]]) was measured in adult [[start|Lifelines]] participants during [[1A Visit 1]] (n = ~84.000, n = ~76,000 after rigorous quality control). |
| ===== Background ===== | ===== Background ===== | ||
| SAF was measured in Lifelines participants using the [[https://www.diagnoptics.com/nl/age-reader|AGE Reader]], a noninvasive instrument to determine the accumulation of [[https://en.wikipedia.org/wiki/Advanced_glycation_end-product|Advanced Glycation Endproducts]] (AGEs) in the skin of the forearm.\\ | SAF was measured in Lifelines participants using the [[https://www.diagnoptics.com/nl/age-reader|AGE Reader]], a noninvasive instrument to determine the accumulation of [[https://en.wikipedia.org/wiki/Advanced_glycation_end-product|Advanced Glycation Endproducts]] (AGEs) in the skin of the forearm.\\ | ||
| Increased AGE levels are associated with ageing and development of several chronic diseases such as diabetes, renal insufficiency, and cardiovascular disease.AGEs are glycated proteins or lipids as a result of exposure to sugars (the [[https://en.wikipedia.org/wiki/Maillard_reaction|Maillard reaction]]). The presence of AGEs increases the level of SAF, and indeed SAF levels are increased in patients with diabetes, renal failure and in patients with vascular complications. Moreover, SAF is strongly related to the progression of coronary heart disease and mortality, independently of traditional risk factors.\\ | Increased AGE levels are associated with ageing and development of several chronic diseases such as diabetes, renal insufficiency, and cardiovascular disease.AGEs are glycated proteins or lipids as a result of exposure to sugars (the [[https://en.wikipedia.org/wiki/Maillard_reaction|Maillard reaction]]). The presence of AGEs increases the level of SAF, and indeed SAF levels are increased in patients with diabetes, renal failure and in patients with vascular complications. Moreover, SAF is strongly related to the progression of coronary heart disease and mortality, independently of traditional risk factors.\\ | ||
| - | In general, SAF-derived AGE values appear to be good predictors of long-term vascular complications in diabetes and in other conditions associated with AGE accumulation ((Mulder DJ et al. (2006). Skin autofluorescence, a novel marker for glycemic and oxidative stress-derived advanced glycation endproducts: an overview of current clinical studies, evidence, and limitations. Diabetes Technology & Therapeutics 8(5):523-535))((Bos DC et al. (2011) Diabetes Technology & Therapeutics 13(7):773-779)).\\ | + | In general, SAF-derived AGE values appear to be good predictors of long-term vascular complications in diabetes and in other conditions associated with AGE accumulation((Mulder DJ et al. (2006). Skin autofluorescence, a novel marker for glycemic and oxidative stress-derived advanced glycation endproducts: an overview of current clinical studies, evidence, and limitations. Diabetes Technology & Therapeutics 8(5):523-535))((Bos DC et al. (2011) Diabetes Technology & Therapeutics 13(7):773-779)).\\ |
| ===== Validation ===== | ===== Validation ===== | ||
skin_autofluorescence.1589801855.txt.gz ยท Last modified: 2025/02/05 14:49 (external edit)
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