spirometry_validation
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| ====== Spirometry validation and reference values ====== | ====== Spirometry validation and reference values ====== | ||
| - | Researchers from the [[https:// | + | Researchers from the [[https:// |
| - | The gender index can be requested in the Lifelines catalogue or by mail (data@lifelines.nl).\\ | + | The spirometry variables |
| ===== Validation ===== | ===== Validation ===== | ||
| - | [[Pulmonary Function Test|Spirometry]] is performed according to Standard Operating Procedures using the WEllch | + | [[Pulmonary Function Test|Spirometry]] is performed according to Standard Operating Procedures using the Welch Allyn SpiroPerfect device. Judgment on technical correctness is performed by a Lifelines assistant, a pulmonologist, |
| * Test performed according to ATS criteria or | * Test performed according to ATS criteria or | ||
| * Test not performed according to ATS criteria, but clinically reliable. | * Test not performed according to ATS criteria, but clinically reliable. | ||
| - | In case both the pulmonologist and the Lifelines assistant judged the technical correctness, | + | In case both the pulmonologist and the Lifelines assistant judged the technical correctness, |
| + | **Important: | ||
| === Validation rules === | === Validation rules === | ||
| To select only technically valid measurements the following rules were applied: | To select only technically valid measurements the following rules were applied: | ||
| | **IF...** | **THEN...** | | | **IF...** | **THEN...** | | ||
| - | |Review specialist is " | + | |Review specialist is " |
| |Review specialist is "Not ATS, not to assess" | |Review specialist is "Not ATS, not to assess" | ||
| - | |Review specialist is missing or "No announcement" | + | |Review specialist is missing or "No announcement" |
| |Review specialist is missing or "No announcement" | |Review specialist is missing or "No announcement" | ||
| |Other case|Spirometry is not technically correct| | |Other case|Spirometry is not technically correct| | ||
| - | \\ | ||
| - | \\ | ||
| ===== Reference values ===== | ===== Reference values ===== | ||
| - | Reference values based on age, height, and sex will be calculated based on the Global Lung Function Initiative (GLI) using the GLI provided syntax codes and databases | + | Reference values based on age, height, and sex are calculated based on the Global Lung Function Initiative (GLI) using the [[https:// |
| - | (https:// | + | |
| + | === Remarks UMCG researcher === | ||
| + | * It is important to note that ethnicity has not been taken into account. Everyone has been treated as Caucasian. | ||
| + | * There are a few adults subjects with a huge difference in height between [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]] resulting in a huge difference in reference values. It is recommended to exclude the adult subjects with a height difference of more than 5 cm using the height variable.\\ | ||
| + | ===== Article ===== | ||
| + | * Mahon, G. M., Koppelman, G. H., & Vonk, J. M. (2021). Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study. Thorax, 76(5), 441-447. DOI: 10.1136/ | ||
| ===== Variables ===== | ===== Variables ===== | ||
| - | | **Questions | + | | **Label English** |
| - | | | | | + | | Technically valid spirometry? |
| - | | | | | + | | predicted FEV1 value (liter) |
| - | | | | | + | | predicted FEV1FVC value (liter) |
| + | | predicted FVC value (liter) | ||
| + | | predicted FEF75 value (liter per second) | ||
| + | | predicted FEF25_75 (liter per second) | ||
| + | | z-score FEV1 value | z-score FEV1 waarde | ||
| + | | z-score FEV1FVC value | z-score FEV1FVC waarde | ||
| + | | z-score FVC value | z-score FVC waarde | ||
| + | | z-score FEF75 value | z-score FEF75 waarde | ||
| + | | z-score FEF25_75 value | z-score FEF25_75 waarde | ||
| + | | Lower limit of normal FEV1 (liter) | ||
| + | | Lower limit of normal FEV1FVC (liter) | ||
| + | | Upper limit of normal FEV1FVC (liter) | ||
| + | | Lower limit of normal FVC (liter) | ||
| + | | Lower limit of normal FEF75 (liter per second) | ||
| + | | Lower limit of normal FEF25_75 (liter per second) | ||
| + | | FEV1 % predicted | ||
| + | | FEV1FVC % predicted | ||
| + | | FVC % predicted | ||
| + | | FEF75 % predicted | ||
| + | | FEF25_75 % predicted | ||
| + | | change in FEV1 2A versus 1A (liter per year) | verandering in FEV1 2A versus 1A (liter per jaar) | fev1_change_all_c_1 | ||
| + | | change in FEV1FVC 2A versus 1A (liter per year) | verandering in FEV1FVC 2A versus 1A (liter per jaar) | fev1fvc_change_all_c_1 | ||
| + | | change in FVC 2A versus 1A (liter per year) | verandering in FVC1 2A versus 1A (liter per jaar) | fvc_change_all_c_1 | ||
| + | | change in FEF75 2A versus 1A (liter per second per year) | verandering in FEF75 2A versus 1A (liter per seconde per jaar) | fef75_change_all_c_1 | ||
| + | | change in FEF25_75 2A versus 1A (liter per second per year) | verandering in FEF25_75 2A versus 1A (liter per seconde per jaar) | fef2575_change_all_c_1 | ||
| + | | difference in body length adults 2A versus 1A | verschil in lichaamslengte volwassenen 2A versus 1A | spirometry_bodylength_all_c_1 | ||
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