spirometry_validation
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====== Spirometry validation and reference values ====== | ====== Spirometry validation and reference values ====== | ||
- | Researchers from the [[https:// | + | Researchers from the [[https:// |
- | The gender index can be requested in the Lifelines catalogue or by mail (data@lifelines.nl).\\ | + | The spirometry variables |
===== Validation ===== | ===== Validation ===== | ||
- | [[Pulmonary Function Test|Spirometry]] is performed according to Standard Operating Procedures using the WEllch | + | [[Pulmonary Function Test|Spirometry]] is performed according to Standard Operating Procedures using the Welch Allyn SpiroPerfect device. Judgment on technical correctness is performed by a Lifelines assistant, a pulmonologist, |
* Test performed according to ATS criteria or | * Test performed according to ATS criteria or | ||
* Test not performed according to ATS criteria, but clinically reliable. | * Test not performed according to ATS criteria, but clinically reliable. | ||
- | In case both the pulmonologist and the Lifelines assistant judged the technical correctness, | + | In case both the pulmonologist and the Lifelines assistant judged the technical correctness, |
+ | **Important: | ||
=== Validation rules === | === Validation rules === | ||
To select only technically valid measurements the following rules were applied: | To select only technically valid measurements the following rules were applied: | ||
| **IF...** | **THEN...** | | | **IF...** | **THEN...** | | ||
- | |Review specialist is " | + | |Review specialist is " |
|Review specialist is "Not ATS, not to assess" | |Review specialist is "Not ATS, not to assess" | ||
- | |Review specialist is missing or "No announcement" | + | |Review specialist is missing or "No announcement" |
|Review specialist is missing or "No announcement" | |Review specialist is missing or "No announcement" | ||
|Other case|Spirometry is not technically correct| | |Other case|Spirometry is not technically correct| | ||
- | \\ | ||
- | \\ | ||
===== Reference values ===== | ===== Reference values ===== | ||
Reference values based on age, height, and sex are calculated based on the Global Lung Function Initiative (GLI) using the [[https:// | Reference values based on age, height, and sex are calculated based on the Global Lung Function Initiative (GLI) using the [[https:// | ||
- | |||
=== Remarks UMCG researcher === | === Remarks UMCG researcher === | ||
* It is important to note that ethnicity has not been taken into account. Everyone has been treated as Caucasian. | * It is important to note that ethnicity has not been taken into account. Everyone has been treated as Caucasian. | ||
- | * There are a few adults subjects with a huge difference in height between [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]] resulting in a huge difference in reference values. It is recommended to exclude the adult subjects with a height difference of more than 5 cm using the height variable. | + | * There are a few adults subjects with a huge difference in height between [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]] resulting in a huge difference in reference values. It is recommended to exclude the adult subjects with a height difference of more than 5 cm using the height variable.\\ |
+ | ===== Article ===== | ||
+ | * Mahon, G. M., Koppelman, G. H., & Vonk, J. M. (2021). Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study. Thorax, 76(5), 441-447. DOI: 10.1136/ | ||
===== Variables ===== | ===== Variables ===== | ||
- | | **Questions | + | | **Label English** |
- | | | | | + | | Technically valid spirometry? |
- | | | | | + | | predicted FEV1 value (liter) |
- | | | | | + | | predicted FEV1FVC value (liter) |
+ | | predicted FVC value (liter) | ||
+ | | predicted FEF75 value (liter per second) | ||
+ | | predicted FEF25_75 (liter per second) | ||
+ | | z-score FEV1 value | z-score FEV1 waarde | ||
+ | | z-score FEV1FVC value | z-score FEV1FVC waarde | ||
+ | | z-score FVC value | z-score FVC waarde | ||
+ | | z-score FEF75 value | z-score FEF75 waarde | ||
+ | | z-score FEF25_75 value | z-score FEF25_75 waarde | ||
+ | | Lower limit of normal FEV1 (liter) | ||
+ | | Lower limit of normal FEV1FVC (liter) | ||
+ | | Upper limit of normal FEV1FVC (liter) | ||
+ | | Lower limit of normal FVC (liter) | ||
+ | | Lower limit of normal FEF75 (liter per second) | ||
+ | | Lower limit of normal FEF25_75 (liter per second) | ||
+ | | FEV1 % predicted | ||
+ | | FEV1FVC % predicted | ||
+ | | FVC % predicted | ||
+ | | FEF75 % predicted | ||
+ | | FEF25_75 % predicted | ||
+ | | change in FEV1 2A versus 1A (liter per year) | verandering in FEV1 2A versus 1A (liter per jaar) | fev1_change_all_c_1 | ||
+ | | change in FEV1FVC 2A versus 1A (liter per year) | verandering in FEV1FVC 2A versus 1A (liter per jaar) | fev1fvc_change_all_c_1 | ||
+ | | change in FVC 2A versus 1A (liter per year) | verandering in FVC1 2A versus 1A (liter per jaar) | fvc_change_all_c_1 | ||
+ | | change in FEF75 2A versus 1A (liter per second per year) | verandering in FEF75 2A versus 1A (liter per seconde per jaar) | fef75_change_all_c_1 | ||
+ | | change in FEF25_75 2A versus 1A (liter per second per year) | verandering in FEF25_75 2A versus 1A (liter per seconde per jaar) | fef2575_change_all_c_1 | ||
+ | | difference in body length adults 2A versus 1A | verschil in lichaamslengte volwassenen 2A versus 1A | spirometry_bodylength_all_c_1 |
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