spirometry_validation
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spirometry_validation [2025/02/05 14:49] (current) |
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| ====== Spirometry validation and reference values ====== | ====== Spirometry validation and reference values ====== | ||
| - | Researchers from the [[https://www.rug.nl/staff/j.m.vonk/|University Medical Center Groningen]] performed a validation of the [[Pulmonary Function Test]] from participants at [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]] ([[sections]]: [[physical state]] ([[Pulmonary Function Test]]) and [[secondary & linked variables]]).\\ | + | Researchers from the [[https://www.rug.nl/staff/j.m.vonk/|University Medical Center Groningen]] performed a validation of the [[Pulmonary Function Test]] from participants at [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]]. Additionally, reference values have been developed. ([[sections]]: [[physical state]] ([[Pulmonary Function Test]]) and [[secondary & linked variables]]).\\ |
| - | The spirometry variables can be requested in the Lifelines catalogue (coming soon) or by mail (data@lifelines.nl).\\ | + | The spirometry variables can be requested in the [[https://data-catalogue.lifelines.nl/|Lifelines catalogue]].\\ |
| ===== Validation ===== | ===== Validation ===== | ||
| - | [[Pulmonary Function Test|Spirometry]] is performed according to Standard Operating Procedures using the WEllch Allyn SpiroPerfect device. Judgment on technical correctness is performed by a Lifelines assistant, a pulmonologist, or both, according to a standard review procedure. Only data from pulmonary function tests that are judged to be technically correct should be used in the analyses. Technically correct is defined as: | + | [[Pulmonary Function Test|Spirometry]] is performed according to Standard Operating Procedures using the Welch Allyn SpiroPerfect device. Judgment on technical correctness is performed by a Lifelines assistant, a pulmonologist, or both, according to a standard review procedure. Only data from pulmonary function tests that are judged to be technically correct should be used in the analyses. Technically correct is defined as: |
| * Test performed according to ATS criteria or | * Test performed according to ATS criteria or | ||
| * Test not performed according to ATS criteria, but clinically reliable. | * Test not performed according to ATS criteria, but clinically reliable. | ||
| - | In case both the pulmonologist and the Lifelines assistant judged the technical correctness, the priority is given to the judgment of the pulmonologist. | + | In case both the pulmonologist and the Lifelines assistant judged the technical correctness, the priority is given to the judgment of the pulmonologist.\\ |
| + | **Important:** part of the spirometry results have been listed as technically invalid, as a result the researchers from the UMCG recommend you to __NOT__ use these results in analyses.\\ | ||
| === Validation rules === | === Validation rules === | ||
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| |Other case|Spirometry is not technically correct| | |Other case|Spirometry is not technically correct| | ||
| - | \\ | ||
| - | \\ | ||
| ===== Reference values ===== | ===== Reference values ===== | ||
| Reference values based on age, height, and sex are calculated based on the Global Lung Function Initiative (GLI) using the [[https://www.ers-education.org/guidelines/global-lung-function-initiative.aspx|GLI provided syntax codes and databases]]. | Reference values based on age, height, and sex are calculated based on the Global Lung Function Initiative (GLI) using the [[https://www.ers-education.org/guidelines/global-lung-function-initiative.aspx|GLI provided syntax codes and databases]]. | ||
| - | |||
| === Remarks UMCG researcher === | === Remarks UMCG researcher === | ||
| * It is important to note that ethnicity has not been taken into account. Everyone has been treated as Caucasian. | * It is important to note that ethnicity has not been taken into account. Everyone has been treated as Caucasian. | ||
| - | * There are a few adults subjects with a huge difference in height between [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]] resulting in a huge difference in reference values. It is recommended to exclude the adult subjects with a height difference of more than 5 cm using the height variable. | + | * There are a few adults subjects with a huge difference in height between [[1a_visit_1|1A visit 1]] and [[2a_visit_1|2A visit 1]] resulting in a huge difference in reference values. It is recommended to exclude the adult subjects with a height difference of more than 5 cm using the height variable.\\ |
| + | ===== Article ===== | ||
| + | * Mahon, G. M., Koppelman, G. H., & Vonk, J. M. (2021). Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study. Thorax, 76(5), 441-447. DOI: 10.1136/thoraxjnl-2020-215232\\ | ||
| ===== Variables ===== | ===== Variables ===== | ||
| - | | **Questions English** | **Questions Dutch** | **Code** | **Variable** | **Assessment** | **Age** | | + | | **Label English** | **Label Dutch** | **Code** | **Variable** | **Assessment** | **Age** | |
| - | | Identifier for technically correct spirometry (baseline) | | | spiro_ok_baseline | [[1A]] | 8+ | | + | | Technically valid spirometry? | Technisch correcte spirometrie? | spirometry_valid_all_c_1 | spiro_ok | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FEV1 value at baseline | | | FEV1_predicted_baseline | [[1A]] | 8+ | | + | | predicted FEV1 value (liter) | voorspelde FEV1 waarde (liter) | fev1_predicted_all_c_1 | FEV1_predicted | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FEV1FVC value at baseline | | | FEV1FVC_predicted_baseline | [[1A]] | 8+ | | + | | predicted FEV1FVC value (liter) | voorspelde FEV1FVC waarde (liter) | fev1fvc_predicted_all_c_1 | FEV1FVC_predicted | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FVC value at baseline | | | FVC_predicted_baseline | [[1A]] | 8+ | | + | | predicted FVC value (liter) | voorspelde FVC waarde (liter) | fcv_predicted_all_c_1 | FVC_predicted | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FEF75 value at baseline | | | FEF75_predicted_baseline | [[1A]] | 8+ | | + | | predicted FEF75 value (liter per second) | voorspelde FEF75 waarde (liter per seconde) | fef75_predicted_all_c_1 | FEF75_predicted | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FEF25_75 at baseline | | | FEF2575_predicted_baseline | [[1A]] | 8+ | | + | | predicted FEF25_75 (liter per second) | voorspelde FEF25_75 waarde (liter per seconde) | fef2575_predicted_all_c_1 | FEF2575_predicted | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Zscore FEV1 value at baseline | | | FEV1_zscore_baseline | [[1A]] | 8+ | | + | | z-score FEV1 value | z-score FEV1 waarde | fev1_zscore_all_c_1 | FEV1_zscore | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Zscore FEV1FVC value at baseline | | | FEV1FVC_zscore_baseline | [[1A]] | 8+ | | + | | z-score FEV1FVC value | z-score FEV1FVC waarde | fev1fvc_zscore_all_c_1 | FEV1FVC_zscore | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Zscore FVC value at baseline | | | FVC_zscore_baseline | [[1A]] | 8+ | | + | | z-score FVC value | z-score FVC waarde | fcv_zscore_all_c_1 | FVC_zscore | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Zscore FEF75 value at baseline | | | FEF75_zscore_baseline | [[1A]] | 8+ | | + | | z-score FEF75 value | z-score FEF75 waarde | fef75_zscore_all_c_1 | FEF75_zscore | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Zscore FEF25_75 value at baseline | | | FEF2575_zscore_baseline | [[1A]] | 8+ | | + | | z-score FEF25_75 value | z-score FEF25_75 waarde | fef2575_zscore_all_c_1 | FEF2575_zscore | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Lower limit of normal FEV1 at baseline | | | FEV1_LLN_baseline | [[1A]] | 8+ | | + | | Lower limit of normal FEV1 (liter) | Ondergrens van normale FEV1 (liter) | fev1_lowerlimit_all_c_1 | FEV1_LLN | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Lower limit of normal FEV1FVC at baseline | | | FEV1FVC_LLN_baseline | [[1A]] | 8+ | | + | | Lower limit of normal FEV1FVC (liter) | Ondergrens van normale FEV1FVC (liter) | fev1fvc_lowerlimit_all_c_1 | FEV1FVC_LLN | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Upper limit of normal FEV1FVC at baseline | | | FEV1FVC_ULN_baseline | [[1A]] | 8+ | | + | | Upper limit of normal FEV1FVC (liter) | Bovengrens van normale FEV1FVC (liter) | fev1fvc_upperlimit_all_c_1 | FEV1FVC_ULN | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Lower limit of normal FVC at baseline | | | FVC_LLN_baseline | [[1A]] | 8+ | | + | | Lower limit of normal FVC (liter) | Ondergrens van normale FVC (liter) | fvc_lowerlimit_all_c_1 | FVC_LLN | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Lower limit of normal FEF75 at baseline | | | FEF75_LLN_baseline | [[1A]] | 8+ | | + | | Lower limit of normal FEF75 (liter per second) | Ondergrens van normale FEF75 (liter per seconde) | fef75_lowerlimit_all_c_1 | FEF75_LLN | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Lower limit of normal FEF25_75 at baseline | | | FEF2575_LLN_baseline | [[1A]] | 8+ | | + | | Lower limit of normal FEF25_75 (liter per second) | Ondergrens van normale FEF25_75 (liter per seconde) | fef2575_lowerlimit_all_c_1 | FEF2575_LLN | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | FEV1 % predicted at baseline | | | fev1pp_baseline | [[1A]] | 8+ | | + | | FEV1 % predicted | FEV1 % voorspeld | fev1_percpredicted_all_c_1 | fev1pp | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | FVC % predicted at baseline | | | fvcpp_baseline | [[1A]] | 8+ | | + | | FEV1FVC % predicted | FEV1FVC % voorspeld | fev1fvc_percpredicted_all_c_1 | fev1fvcpp | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | FEV1FVC % predicted at baseline | | | fev1fvcpp_baseline | [[1A]] | 8+ | | + | | FVC % predicted | FVC % voorspeld | fvc_percpredicted_all_c_1 | fvcpp | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | FEF75 % predicted at baseline | | | fef75pp_baseline | [[1A]] | 8+ | | + | | FEF75 % predicted | FEF75 % voorspeld | fef75_percpredicted_all_c_1 | fef75pp | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | FEF2575 % predicted at baseline | | | fef2575pp_baseline | [[1A]] | 8+ | | + | | FEF25_75 % predicted | FEF25_75 % voorspeld | fef2575_percpredicted_all_c_1 | fef2575pp | [[1A visit 1|1A]] [[2A visit 1|2A]] | 18+ | |
| - | | Identifier for technically correct spirometry (second assessment) | | | spiro_ok_2ndass | [[2A]] | 18+ | | + | | change in FEV1 2A versus 1A (liter per year) | verandering in FEV1 2A versus 1A (liter per jaar) | fev1_change_all_c_1 | dfev1 | [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FEV1 value at 2ndass | | | FEV1_predicted_2ndass | [[2A]] | 18+ | | + | | change in FEV1FVC 2A versus 1A (liter per year) | verandering in FEV1FVC 2A versus 1A (liter per jaar) | fev1fvc_change_all_c_1 | dfev1fvc | [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FEV1FVC value at 2ndass | | | FEV1FVC_predicted_2ndass | [[2A]] | 18+ | | + | | change in FVC 2A versus 1A (liter per year) | verandering in FVC1 2A versus 1A (liter per jaar) | fvc_change_all_c_1 | dfvc | [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FVC value at 2ndass | | | FVC_predicted_2ndass | [[2A]] | 18+ | | + | | change in FEF75 2A versus 1A (liter per second per year) | verandering in FEF75 2A versus 1A (liter per seconde per jaar) | fef75_change_all_c_1 | dfef75 | [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FEF75 value at 2ndass | | | FEF75_predicted_2ndass | [[2A]] | 18+ | | + | | change in FEF25_75 2A versus 1A (liter per second per year) | verandering in FEF25_75 2A versus 1A (liter per seconde per jaar) | fef2575_change_all_c_1 | dfef2575 | [[2A visit 1|2A]] | 18+ | |
| - | | Predicted FEF25_75 at 2ndass | | | FEF2575_predicted_2ndass | [[2A]] | 18+ | | + | | difference in body length adults 2A versus 1A | verschil in lichaamslengte volwassenen 2A versus 1A | spirometry_bodylength_all_c_1 | heightdifference_adults | [[2A visit 1|2A]] | 18+ | |
| - | | Zscore FEV1 value at 2ndass | | | FEV1_zscore_2ndass | [[2A]] | 18+ | | + | |
| - | | Zscore FEV1FVC value at 2ndass | | | FEV1FVC_zscore_2ndass | [[2A]] | 18+ | | + | |
| - | | Zscore FVC value at 2ndass | | | FVC_zscore_2ndass | [[2A]] | 18+ | | + | |
| - | | Zscore FEF75 value at 2ndass | | | FEF75_zscore_2ndass | [[2A]] | 18+ | | + | |
| - | | Zscore FEF25_75 value at 2ndass | | | FEF2575_zscore_2ndass | [[2A]] | 18+ | | + | |
| - | | Lower limit of normal FEV1 at 2ndass | | | FEV1_LLN_2ndass | [[2A]] | 18+ | | + | |
| - | | Lower limit of normal FEV1FVC at 2ndass | | | FEV1FVC_LLN_2ndass | [[2A]] | 18+ | | + | |
| - | | Upper limit of normal FEV1FVC at 2ndass | | | FEV1FVC_ULN_2ndass | [[2A]] | 18+ | | + | |
| - | | Lower limit of normal FVC at 2ndass | | | FVC_LLN_2ndass | [[2A]] | 18+ | | + | |
| - | | Lower limit of normal FEF75 at 2ndass | | | FEF75_LLN_2ndass | [[2A]] | 18+ | | + | |
| - | | Lower limit of normal FEF25_75 at 2ndass | | | FEF2575_LLN_2ndass | [[2A]] | 18+ | | + | |
| - | | FEV1 % predicted at 2ndass | | | fev1pp_2ndass | [[2A]] | 18+ | | + | |
| - | | FVC % predicted at 2ndass | | | fvcpp_2ndass | [[2A]] | 18+ | | + | |
| - | | FEV1FVC % predicted at 2ndass | | | fev1fvcpp_2ndass | [[2A]] | 18+ | | + | |
| - | | FEF75 % predicted at 2ndass | | | fef75pp_2ndass | [[2A]] | 18+ | | + | |
| - | | FEF2575 % predicted at 2ndass | | | fef2575pp_2ndass | [[2A]] | 18+ | | + | |
| - | | Change in FEV1 (L/year) between baseline and 2ndass | | | dfev1 | | | | + | |
| - | | Change in FVC (L/year) between baseline and 2ndass | | | dfvc | | | | + | |
| - | | Cchange in FEV1FVC (per year) between baseline and 2ndass | | | dfev1fvc | | | | + | |
| - | | Change in FEF75 ((L/sec)/year) between baseline and 2ndass | | | dfef75 | | | | + | |
| - | | Change in FEF2575 ((L/sec)/year) between baseline and 2ndass | | | dfef2575 | | | | + | |
| - | | Difference in height between baseline and 2ndass | | | heightdifference_adults | | | | + | |
spirometry_validation.1618498885.txt.gz · Last modified: 2025/02/05 14:49 (external edit)
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