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====== Fatigue (CDC) ======

The [[https://www.cdc.gov/me-cfs/index.html|Centers for Disease Control and Prevention (CDC)]] symptom inventory for [[https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome|chronic fatigue syndrome]] (CFS or ME) is aimed to assess whether a person meets the CDC diagnostic criteria for (CFS)((van't Leven M et al. (2010). Fatigue and chronic fatigue syndrome-like complaints in the general population. European Journal of Public Health 20: 251-257)) ([[sections|section]]: [[diseases & symptoms]]).\\
Note that Lifelines also assesses (chronic) fatigue using the [[fatigue (CIS)|CIS]] and [[general health (PROMIS)|PROMIS]] instruments plus some [[fatigue (general)|general questions]]. An [[cfs_diagnostic_score|CFS diagnostic score]] according to the CDC has been developed and is available for use.

===== Background =====
Lifelines repeatedly assessed the presence of CFS/ME by [[fatigue (general)|self-report]]. However, recent studies indicate that this method misses ~90% of the CFS diagnoses((Warren JW, Clauw DJ (2012). Functional somatic syndromes: sensitivities and specificities of self-reports of physician diagnosis. Psychosomatic Medicine 74(9):891-895)). The CDC symptom survey improves the identification of participants that meet the diagnostic criteria for CFS/ME by assessing the presence of individual symptoms rather than the disease itself.

The CDC symptom survey was developed in English and translated in Dutch ((Ruud CW Vermeulen (2006) Translation and validation of the Dutch language version of the CDC Symptom Inventory for assessment of Chronic Fatigue Syndrome (CFS). Population Health Metrics 4(12) )).\\
The CDC symptom survey as used in Lifelines assesses 8 symptoms that are part of the diagnostic criteria for CSF, plus a question regarding depressive feelings in the last 6 months to increase the diagnostic value.\\ 
To assess fatigue, the core symptom of CFS, an additional question was asked in conjuction to the CDC (see [[fatigue (general)|here]]).\\

===== Validation =====

The validation of the CDC symptom survey is described here((Wagner et al. (2005) Psychometric properties of the CDC Symptom Inventory for assessment of Chronic Fatigue Syndrome. Population Health Metrics 3(8) ))

===== Variables =====

| **Questions English**                                                                                                       | **Questions Dutch**                                                                                                             | **Code**                      | **Variable**  | **Assessment**                                                                               | **Age**  |
| forgetfulness / how often did you have the complaints listed below in the past 6 months?                                    | vergeetachtigheid / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                                | cdc_forgetful_adu_q_01        | CDC1          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| forgetfulness / have you had these complaints for more than or less than 6 months?                                          | vergeetachtigheid / hebt u korter of langer dan 6 maanden last van deze klachten?                                               | cdc_forgetful_adu_q_01_a      | CDC1A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| problems concentrating / how often did you have the complaints listed below in the past 6 months?                           | concentratieproblemen / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                            | cdc_concentration_adu_q_02    | CDC2          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| problems concentrating / have you had these complaints for more than or less than 6 months?                                 | concentratieproblemen / hebt u korter of langer dan 6 maanden last van deze klachten?                                           | cdc_concentration_adu_q_02_a  | CDC2A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| sore throat / how often did you have the complaints listed below in the past 6 months?                                      | keelpijn / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                                         | cdc_sorethroat_adu_q_03       | CDC3          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| sore throat / have you had these complaints for more than or less than 6 months?                                            | keelpijn / hebt u korter of langer dan 6 maanden last van deze klachten?                                                        | cdc_sorethroat_adu_q_03_a     | CDC3A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| tender neck or axillary nodes / how often did you have the complaints listed below in the past 6 months?                    | gevoelige hals- of okselklieren / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                  | cdc_tendernodes_adu_q_04      | CDC4          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| tender neck or axillary nodes / have you had these complaints for more than or less than 6 months?                          | gevoelige hals- of okselklieren / hebt u korter of langer dan 6 maanden last van deze klachten?                                 | cdc_tendernodes_adu_q_04_a    | CDC4A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| sore muscles / how often did you have the complaints listed below in the past 6 months?                                     | spierpijn / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                                        | cdc_musclepain_adu_q_05       | CDC5          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| sore muscles / have you had these complaints for more than or less than 6 months?                                           | spierpijn / hebt u korter of langer dan 6 maanden last van deze klachten?                                                       | cdc_musclepain_adu_q_05_a     | CDC5A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| painful joints / how often did you have the complaints listed below in the past 6 months?                                   | pijnlijke gewrichten / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                             | cdc_jointpain_adu_q_06        | CDC6          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| painful joints / have you had these complaints for more than or less than 6 months?                                         | pijnlijke gewrichten / hebt u korter of langer dan 6 maanden last van deze klachten?                                            | cdc_jointpain_adu_q_06_a      | CDC6A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| headache / how often did you have the complaints listed below in the past 6 months?                                         | hoofdpijn / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                                        | cdc_headache_adu_q_07         | CDC7          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| headache / have you had these complaints for more than or less than 6 months?                                               | hoofdpijn / hebt u korter of langer dan 6 maanden last van deze klachten?                                                       | cdc_headache_adu_q_07_a       | CDC7A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| waking up not feeling rested / how often did you have the complaints listed below in the past 6 months?                     | niet uitgerust wakker worden / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                     | cdc_notrested_adu_q_08        | CDC8          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| waking up not feeling rested / have you had these complaints for more than or less than 6 months?                           | niet uitgerust wakker worden / hebt u korter of langer dan 6 maanden last van deze klachten?                                    | cdc_notrested_adu_q_08_a      | CDC8A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| worsening of complaints after physical activity / how often did you have the complaints listed below in the past 6 months?  | toename van klachten na lichamelijke inspanning / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?  | cdc_complaints_adu_q_09       | CDC9          | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| worsening of complaints after physical activity / have you had these complaints for more than or less than 6 months?        | toename van klachten na lichamelijke inspanning / hebt u korter of langer dan 6 maanden last van deze klachten?                 | cdc_complaints_adu_q_09_a     | CDC9A         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| depressed feelings / how often did you have the complaints listed below in the past 6 months?                               | depressieve gevoelens / hoe vaak hebt u de afgelopen 6 maanden last gehad van onderstaande klachten?                            | cdc_depressive_adu_q_10       | CDC10         | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
| depressed feelings / have you had these complaints for more than or less than 6 months?                                     | depressieve gevoelens / hebt u korter of langer dan 6 maanden last van deze klachten?                                           | cdc_depressive_adu_q_10_a     | CDC10A        | [[2A Questionnaire 2|2A]] [[3A Questionnaire 1|3A]] [[4A Questionnaire Sleep| 4A]] [[NEXT]]  | 18+      |
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