Table of Contents

Heart rate variability validation and derivatives

Researchers from the University Medical Center Groningen performed a validation of the ECG from participants at 1A visit 1 and 2A visit 1. Additionally, derivative variables have been created. (sections: physical state (ECG) and secondary & linked variables))

The heart rate variability (HRV) variables can be requested in the Lifelines catalogue.

Validation

For participants 13 years or older, 10 second single 12 –lead resting electrocardiogram ECG was recorded using Cardioperfect software (Welch Allyn DT100 recorder, Welch Allyn, Skaneateles Falls, NY). To calculate heart rate variability (HRV), ECG signals were extracted from the Lifelines ECG database. Lifelines cardiologistst inspected all the ECG signals to determine whether the ECG could be used or not. ECG signals were retrieved from the Lifelines ECG database using an in-house software developed by Dr. van Roon from Department of Vascular Medicine (UMCG) in collaboration with Prof. Snieder at Department of Epidemiology (UMCG). This software semi-automatically calculates the HRV indices. All ECG recordings with arrhythmia, pacemaker, and triggering failure were excluded.

Derivatives

Using the ECG recordings that passed the validation stage, some derivative variables were calculated:

  1. new HRV indices corrected for the effect of mean interbeat interval using coefficient of variation
  2. ln-transformation of HRV indices (because of skewed distribution)
  3. identification of outliers (value above/below 5SDs from the mean)

Additionally, a correction has been performed in case two ECG measurements were available for one participant: the measurement with the lowest mean interbeat interval was excluded.


Variables

Label English Label Dutch Code Variable Assessment Age
status ECG recording status ECG opname ecg_status_adu_c_1 Status 1A 2A 13+
mean interbeat interval (ms) gemiddelde interbeat interval (ms) ibi_mean_adu_c_1 mIBI 1A 2A 13+
extreme value for mean interbeat interval (>5SD from mean) extreme waarde voor gemiddelde interbeat interval (>5SD van het gemiddelde) ibi_mean_adu_c_1_o mIBI_outlier 1A 2A 13+
number of heart beats used to calculate mean and standard deviation of the interbeat interval aantal gebruikte hartslagen voor berekening van gemiddelde en standaarddeviatie van het interbeat interval ibi_number_adu_c_1 nIBI 1A 2A 13+
log-transformed root mean square of successive differences (ms) log-getransformeerde vierkantswortel van opeenvolgende verschillen (ms) rmssd_ln_adu_c_1 lnRMSSD 1A 2A 13+
extreme value for log-transformed root mean square of successive differences (>5SD from mean) extreme waarde voor log-getransformeerde vierkantswortel van opeenvolgende verschillen (>5SD van het gemiddelde) rmssd_ln_adu_c_1_o lnRMSSD_outlier 1A 2A 13+
log-transformed root mean square of successive differences corrected for heart rate (ms) log-getransformeerde vierkantswortel van opeenvolgende verschillen gecorrigeerd voor hartslag (ms) rmssd_lncorrected_adu_c_1 lnRMSSDc 1A 2A 13+
extreme value for log-transformed root mean square of successive differences corrected for heart rate (>5SD from mean) extreme waarde voor log-getransformeerde vierkantswortel van opeenvolgende verschillen gecorrigeerd voor hartslag rmssd_lncorrected_adu_c_1_o lnRMSSDc_outlier 1A 2A 13+
root mean square of successive differences (ms) vierkantswortel van opeenvolgende verschillen (ms) rmssd_ms_adu_c_1 RMSSD 1A 2A 13+
root mean square of successive differences corrected for heart rate (ms) vierkantswortel van opeenvolgende verschillen gecorrigeerd voor hartslag (ms) rmssd_mscorrected_adu_c_1 RMSSDc 1A 2A 13+
log-transformed standard deviation of interbeat interval (ms) log-getransformeerde standaarddeviatie van het interbeat interval (ms) sdnn_ln_adu_c_1 lnSDNN 1A 2A 13+
extreme value for log-transformed standard deviation of interbeat interval (>5SD from mean) extreme waarde voor log-getransformeerde standaarddeviatie van het interbeat interval (>5SD van het gemiddelde) sdnn_ln_adu_c_1_o lnSDNN_outlier 1A 2A 13+
log-transformed standard deviation of interbeat interval corrected for heart rate (ms) log-getransformeerde standaarddeviatie van het interbeat interval gecorrigeerd voor hartslag (ms) sdnn_lncorrected_adu_c_1 lnSDNNc 1A 2A 13+
extreme value for log-transformed standard deviation of interbeat interval corrected for heart rate (>5SD from mean) extreme waarde voor log-getransformeerde standaarddeviatie van het interbeat interval gecorrigeerd voor hartslag (>5SD van het gemiddelde) sdnn_lncorrected_adu_c_1_o lnSDNNc_outlier 1A 2A 13+
standard deviation of interbeat interval (ms) standaarddeviatie van het interbeat interval (ms) sdnn_ms_adu_c_1 SDNN 1A 2A 13+
standard deviation of interbeat interval corrected for heart rate (ms) standaarddeviatie van het interbeat interval gecorrigeerd voor hartslag (ms) sdnn_mscorrected_adu_c_1 SDNNc 1A 2A 13+
number of values used to calculate mean, standard deviation and root mean square of successive differences of interbeat interval aantal gebruikte waarden voor berekening van gemiddelde, standaarddeviatie en vierkantswortel van opeenvolgende verschillen van het interbeat interval ssd_number_adu_c_1 nSSD 1A 2A 13+



Papers using HRV data